امروز : یکشنبه   ۲۸. آبان ۱۳۹۶   /    29. صفر 1439   /    19. نوامبر 2017

Solitary Osseous Plasmacytoma of the Head and Neck

Solitary Osseous Plasmacytoma of the Head and Neck
Bijan Khademi1, Zohreh Zandifar2, Sayed Hasan Hamedi3, Samiraz Razzaghi3 Sareh Mahdavi4, Negar Azarpira5, and Mohammad Mohammadianpanah6
1 Shiraz institute for Cancer Research, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Otolaryngology, and Head and neck surgery, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz71936-13511, Iran
3 Department of Radiation Oncology, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
4 School of Dentistry, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

5 Organ Transplant Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
6 Colorectal Research Center, Department of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran 
Abstract

Purpose: This study aimed to report the characteristics and treatment outcome of 8 patients with solitary osseous plasmacytoma of the head and neck with special focus on mandibular plasmacytoma.  
Materials and Methods: The study was conducted on 8 patients with solitary osseous plasmacytoma of the head and neck who were treated at two academic tertiary referral hospitals between 1999 and 2010. All the patients were treated with curative intent.
Four  patients  (50%)  were  primarily  treated  with  radiotherapy  alone  at  initial  diagnosis,  one  patient  (12.5%)  underwent  surgery
alone, and 3 patients (37.5%) were treated with gross tumor resection followed by radiotherapy. The median total radiation dose was 46 (range 30-50) GY. 
Results: There were 4 women and 4 men aging from 37 to 73 years, with a median and mean age of 52 years at diagnosis. Pain (in 7 cases) and swelling (in 5 cases) were the most common presentations. Mandible (in 4 cases) was the most frequent primary site. The  median  tumor  size  was  4.8  (range 3.5-6)  cm.  After  a  median follow-up  of 44  months  (range 27-79  months), 5  patients  are alive and without disease, one is alive with multiple myeloma, and two died of multiple myeloma.  
Conclusion:  Solitary  osseous  plasmacytomas of  the  head  and  neck have  a  propensity  to  involve  the  mandibular  bones  and response  well  to  effective local treatments of  radiotherapy  and/or surgery.  These Patients  tend to progress to  multiple  myeloma even years after the initial treatment.

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