امروز : یکشنبه   ۰۲. مهر ۱۳۹۶   /    3. محرم 1439   /    24. سپتامبر 2017

The Healing Effect of Strawberry Extract on Acetic Acid-Induced Ulcerative Colitis in Rat

Abstract:  

Ulcerative  colitis  (UC)  is  a  relapsing  multi-factorial  inflammatory disease of the large intestine.
This study determined the healing effect of strawberry extract on acetic acid-induced UC in rat. Two milliliters
of 3% acetic acid was administered into the colon to induce UC. Eighty four rats were divided into seven equal
groups. Group I was a negative control receiving 0.5 ml/kg of normal saline after induction of UC; Group II as
positive control received 2 ml of intra-colonic asacol; groups III and IV received 10% and 20% of strawberry
extract  trans-rectally;  Group  Vreceived  the  gel  base trans-rectally and groups VI and VII received 200 and
400 mg/kg of strawberry extract orally. All animals were evaluated for weight change, histological assessment
and malondialdehyde (MDA) activity. Strawberry extract in the two forms of trans-rectal and oral administration
on third and seventh day after therapy could increase the body weight and result into a more healing effect in
acetic acid-induced damaged colonic tissue and with a reduction in MDA activity. In trans-rectal administration,
20% gel form had a better healing response than 10% gel form and were prominently more on the seventh day
of therapy. In oral administration of strawberry extract, the 400 mg/kg dosage had a better healing response than
200 mg/kg and was significantly more on the seventh day of therapy. So strawberry may be considered as a
treatment of choice for UC especially in gel form to broaden the current therapy options of the disease.

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