امروز : یکشنبه   ۰۲. مهر ۱۳۹۶   /    3. محرم 1439   /    24. سپتامبر 2017

Assessing two methods of repair of duodenal defects, jeujenal serosal patch and jejunal pedicled flap, (an experimental animal study)

Assessing two methods of repair of duodenal defects, jeujenal serosal patch and jejunal pedicled flap, (an experimental animal study)

Abstract

Objective: To evaluate the outcomes of jejunal serosal patch and jejunal pedicled flap procedures for the repair of duodenal injuries.
Methods: The experimental animal-model study was conducted at Shiraz University of Medical Sciences, Iran, in February 2013. Ten mixed-breed male dogs were selected and randomly divided into groups A and B. After general anaesthesia, a large duodenal defect was created in all animals. The defect was repaired with jejunal pedicled flap in group A and jejunal serosal patch in group B. Microscopic healing was scored according to epithelialisation, collagenisation, inflammation, ulcer and necrosis of samples. Kolmogorov-Smirnov and independent t-test were used to indicate normal distributions of data and statistical differences between the two groups respectively.
Results: The weight of the animals ranged between 23 and 37kg and the age range was 12-16 months. All dogs survived the procedures. Anastomotic leakage, intra-abdominal abscess or intestinal obstructions were not detected in gross examination. Healing score was significantly higher in the group A than group B (p0.05).
Conclusion: Applying jejunal pedicled flap for repairing large duodenal defects would lead to better histologic outcomes compared to jejunal serosal patch in dogs.
Keywords: Duodenal injury, Wound healing, Experimental study, Surgery. (JPMA 64: 907; 2014).

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