امروز : یکشنبه   ۲۸. آبان ۱۳۹۶   /    29. صفر 1439   /    19. نوامبر 2017

Ulcerative Colitis and Limb Loss: A Case Report

Ulcerative Colitis and Limb Loss: A Case Report

Introduction: Protein C is a precursor of a vitamin K-dependent serine protease, which is activated by thrombin in the presence of endothelial cofactor, thrombomodulin and endothelial cell protein C receptor.

Case Presentation: A 33-year old woman with acute exacerbation of ulcerative colitis was found to have protein C deficiency (serum protein C activity estimated as 35% of the normal activity). Protein C deficiency was diagnosed after the onset of several arterial thromboemboli complications (brachiocephalic and popliteal artery thrombosis) during her hospital admission for exacerbation of ulcerative colitis (UC). Therefore, upper limb below elbow and lower limb below knee amputation were performed for her.

Conclusions: After total proctocolectomy, serum protein C activity remained as 35% of the normal activity, so the patient used warfarin as lifelong anticoagulant. Investigation of other family members revealed normal thrombophilia screening tests.

Keywords: Thrombophilia; Thromboembolism, Protein C Deficiency; Colitis, Ulcerative

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