امروز : یکشنبه   ۰۲. مهر ۱۳۹۶   /    3. محرم 1439   /    24. سپتامبر 2017

An increased risk of breast cancer associated with Val109Asp polymorphism in omentin gene

Abstract

Breast cancer is the most common malignancy in women. Recent evidence has shown that the combination of factors such as obesity, insulin resistance and alternation in adipokines is associated with the risk and prognosis of breast cancer. Omentin is a newly identified adipokine that is highly expressed in visceral adipose tissue. Theplasma omentin level was inversely correlated with obesity and insulin resistance. This study was aimed to investigate the impact of Val109Asp omentin gene polymorphism with the risk of breast cancer. This case control study was done on 149 breast cancer patients and 150 healthy women as control. Genotyping was determined by restriction fragment length polymorphism (RFLP) analysis of amplified DNA fragments

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