امروز : یکشنبه   ۰۲. مهر ۱۳۹۶   /    3. محرم 1439   /    24. سپتامبر 2017

The Healing Effect of Berberis vulgaris in Acetic Acid-Induced Ulcerative Colitis in Rat

Abstract:
Several anti inflammatory, immunomodulatory and antioxidant effects were reported for anthocyanins noticed in berberry fruits. So they may have beneficial effects in inflammatory bowel diseases (IBD). This study was undertaken to determine the healing effect of Berberis vulgaris in acetic acid-induced ulcerative colitis in rat model. In summer 2010, seventy male Sprague Dawley rats were divided into seven equal groups. Group I received 1 ml of 25% intra-colonic gel form of B. vulgaris extract daily; Group II received 1 ml of 50% intracolonic gel form of B. vulgaris extract daily; Group III received 1 ml of 2000 mg/ml B. vulgaris extract orally per day; Group IV received 1 ml of 1000 mg/ml B. vulgaris extract orally per day; Group V received just intra-colonic gel base; Group VI group received 0.5 ml/kg intracolonic normal saline after induction of colitis as the negative control; and Group VII received 2 ml of asacol intracolonic (0.5 ml asacol that dissolved in 9.5 ml normal saline) as the positive control group. All animals were evaluated for histological investigation and malondialdehyde (MDA) activity. The acetic acid induced inflammation was characterized by neutrophil infiltration, fibrin deposition, submucosal neutrophil margination, submucosal edema, epithelial necrosis and epithelial ulceration.B. vulgaris extract in both forms of intracolonic and oral administration caused a significant decrease in inflammation in acetic acid-induced colonic tissue and significant reduction in MDA activity. So B. vulgaris extract can be a good choice for treatment of UC and can broaden the current treatment options as
an easily available and in-expensive herbal medicine.

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