Epidemiology of Inflammatory Bowel Diseases in Iran and Asia

IJMS Vol 38, No 2, Supplement June 2013

Epidemiology of Inflammatory Bowel Diseases in Iran and Asia; A Mini Review

Ali Reza Safarpour1,2, MD, MPH;  Seyed Vahid Hosseini2, MD;   Davood Mehrabani3, PhD

The prevalence of inflammatory bowel diseases (IBDs) is set to stabilize in Western Europe and North America, as opposed to its increasing trend in developing countries in
Asia. The epidemiology of IBDs in areas where the incidence and prevalence are relatively low provides an opportunity forresearchers to determine the unknown aspects of them. In this review article, the PubMed and MEDLINE databases were searched from 1970 to 2012 and the epidemiological aspects assessed in Iranian articles were compared with identical subjects in other Asian countries. During this period, there were  21 documented articles on IBD epidemiology in Iran and 52 in Asia.
According to the present review, CTLA-gene polymorphism and male/female ratio in ulcerative colitis (UC), incidence of extra-intestinal manifestations, extent of intestinal involvement, and family history in both UC and Crohn’s disease (CD) seemed to be different between Asia and Iran. In contrast, the incidence of primary sclerosing cholangitis in IBD patients and association between NO2/CARD15 mutation and CD as C3435-T allele and UC were nearly the same. The rate of IBD has increased significantly in Iran, as has that of other Asian countries during the last decade. A thorough, well-designed, population-based,multi-regional epidemiologic study seems mandatory due to the
substantial demographic and characteristic variability in IBD patients in our region.
Please cite this article as: Safarpour AR, Hosseini SV, Mehrabani D. Epidemiology of Inflammatory Bowel Diseases in Iran and Asia; A Mini Review. Iran J Med Sci.